After Midnight was played for the first time since December 31, 1999 (208 shows). In Alumni, Trey added "from Goddard College" after the final "'cause I got a degree" lyric. Makisupa included the lyrics "Woke up this morning with a policeman at my door all I could do was shrug, and go back in my bedroom and smoke another nug." This show featured the Phish debut of Night Nurse; original artist Gregory Isaacs passed away the night before, October 25, 2010. Weekapaug was heavily teased by Trey in Mango before the segue into Weekapaug itself. Weekapaug subsequently contained a Can't You Hear Me Knocking jam, which featured lyrics from Ghost and Night Nurse, and was unfinished.