For the second set, the band's "musical costume" was all debuted originals, performed as the invented band Sci-Fi Soldier (a 14-page comic book distributed upon entry detailed the group's adventure to save the planet). For that set, the band performed in elaborate costumes (helmets and all), with alternate instruments (Trey on a BCR Mockingbird), each playing within a flashing/glowing shape (two circles and two squares), after descending (in the form of holograms) from the ceiling in cylinders of colored light. Knuckle Bone Broth Avenue included extended choreography by Trey and Mike. During Get More Down, matching upright geometric shapes danced around behind the band, reducing to the two circles overlapped by Egg in a Hole, which featured pyrotechnics. Before Clear Your Mind, Trey introduced the band as from the year 4680 (the total of the October 28, 2021 songs as noted during that night's encore-ending Grind). During The 9th Cube, there were projections of donuts and turtles on a cube above the band. Fireworks rained down on the stage during The Inner Reaches of Outer. For I Am in Miami, Trey switched to an acoustic guitar and the band stood together at stage front with the four-mic a cappella setup. After the set, the band departed as holograms back up the colored tubes. Soul Planet contained Knuckle Bone Broth Avenue and Don't Doubt Me quotes. Mike quoted Thanksgiving in Death Don't Hurt Very Long. The start of Harry Hood included alternate lyrics (Holy Blankenstein).

The songs in this show were based on animals. Big Black Furry Creature From Mars and Harpua contained Little Squirrel quotes. Shaggy Dog was played for the first time since June 22, 2012 (332 shows). I Am The Walrus was played for the first time since July 29, 2017 (131 shows). and featured Little Squirrel and Shipwreck quotes. Runaway Jim was unfinished and included a Hey, Ho, Nobody Home tease from Trey. Harpua was performed for the first time since July 30, 2017 (130 shows) and featured Carini, Your Pet Cat, and If 6 Was 9 quotes as well as This Jesus Must Die scatting from Trey. Part of Harpua was spoken in French by Page and Mike.

Trey and Mike quoted Little Squirrel throughout the first set (after Olivia’s Pool, and during Axilla and Weekapaug Groove), and during the final vocal chorus of Reba. Trey teased Martian Monster in Mike’s Song and Who Knows in I Always Wanted It This Way. Reba contained a verse with an Ass Handed quote by Trey in the final vocal chorus. Trey teased Tweezer during Sand.

This show featured a setlist with all songs featuring a number in their name in descending order including the Phish debut of If 6 Was 9 and several bustouts: 1999 (last played July 26, 2017, or 131 shows), Five Years (last played October 31, 2016, or 148 shows), Two Versions of Me (last played November 27, 2009, or 436 shows), and NO2 (last played September 6, 2015, or 193 shows). Trey teased L.A. Woman in Also Sprach Zarathustra and Seven Below in First Tube. Page teased Frankenstein in 1999. In place of the usual number of days lived, Grind featured the band singing the setlist ended by noting that the songs added up to “4,680 digits.”

Pebbles and Marbles and Sample in a Jar were unfinished. Makisupa and Weekapaug contained quotes of Little Squirrel. This show featured the Phish debut of The Silver Light. Halley's Comet included an Oye Como Va jam. Blaze On's lyrics were changed to "We'll be dancing at the Bowl." Trey teased Manteca in 46 Days. Weekapaug contained a Piper jam and a Crimes of the Mind tease from Trey.

Moma Dance, Say It To Me S.A.N.T.O.S., Birds of a Feather, Chalk Dust Torture, and Mr. Completely were unfinished. Trey quoted You Enjoy Myself in Moma Dance. The Rover was teased in Simple. Waiting All Night was played over the drumbeat flowing out of Simple. Fee featured Trey on megaphone. L.A. Woman was performed for the first time since December 30, 2003 (493 shows). L.A. Woman, Say It To Me S.A.N.T.O.S., Chalk Dust Torture, Boogie On Reggae Woman, and Carini contained Tweezer teases. L.A. Woman was teased in Say It To Me S.A.N.T.O.S. and Tweezer Reprise. Trey teased Heartbreaker in the second Tweezer. Birds of a Feather contained a Dave's Energy Guide tease from Trey and a Waiting All Night tease from Mike. Chalk Dust Torture also included a Birds of a Feather tease from Trey. This was the rescheduled date from the show that had been postponed due to the coronavirus COVID-19 outbreak in 2020.

Trey teased Dave's Energy Guide before the first set. Fluffhead was unfinished. Trey and Page teased Hey, Ho, Nobody Home in NICU. Trey teased NICU in Tube, Rise/Come Together, Free, and Scents and Subtle Sounds. Llama was performed in an alternate arrangement.

Mike teased Foam in Martian Monster. Trey teased Brother in Soul Planet. My Friend did not contain the "Myfe" ending. Ghost ended with a Julius jam. Trey teased Manteca and Third Stone From the Sun in Everything's Right.

Mike teased Hatikvah in Timber (Jerry the Mule). Trey teased Divided Sky in the first Split Open and Melt. End of Session was performed for the first time since July 25, 2017 (127 shows). Page teased Lonely Trip in Golden Age. This was the rescheduled date from the show that had been postponed due to the coronavirus COVID-19 outbreak in 2020.

This show featured the Phish debut of I Never Left Home. Down with Disease was unfinished and contained a There is a Mountain tease. After Stash, Trey spoke about the two fans who had fallen at the previous show, expressed love and sorrow, and encouraged everyone to be safe. Trey teased Hey, Ho, Nobody Home during Plasma. Trey teased I Always Wanted It This Way in Also Sprach Zarathustra. This was the rescheduled date from the show that had been postponed due to the coronavirus COVID-19 outbreak in 2020.

Steam contained a Dave's Energy Guide tease. Chalk Dust Torture included a Wingsuit tease. This was the rescheduled date from the show that had been postponed due to the coronavirus COVID-19 outbreak in 2020.

Frankie Says was performed for the first time since August 8, 2015 (197 shows), contained Manteca teases from Trey, and ended with Bathtub Gin teases. Moma Dance contained a Monkey Man jam with quotes from Fish. This was the rescheduled date from the show that had been postponed due to the coronavirus COVID-19 outbreak in 2020.

This show featured the debut of And so to Bed which had been previously been released on The White Tape 35 years earlier. Trey quoted Psycho Killer in Sigma Oasis. Tube was unfinished and contained a Tears of the Clown tease from Trey. Brother was restarted after the first verse and was performed for the first time since December 30, 2017 (108 shows). Mike teased "Charge!" after Brother.