For the second set, the band's "musical costume" was all debuted originals, performed as the invented band Sci-Fi Soldier (a 14-page comic book distributed upon entry detailed the group's adventure to save the planet). For that set, the band performed in elaborate costumes (helmets and all), with alternate instruments (Trey on a BCR Mockingbird), each playing within a flashing/glowing shape (two circles and two squares), after descending (in the form of holograms) from the ceiling in cylinders of colored light. Knuckle Bone Broth Avenue included extended choreography by Trey and Mike. During Get More Down, matching upright geometric shapes danced around behind the band, reducing to the two circles overlapped by Egg in a Hole, which featured pyrotechnics. Before Clear Your Mind, Trey introduced the band as from the year 4680 (the total of the October 28, 2021 songs as noted during that night's encore-ending Grind). During The 9th Cube, there were projections of donuts and turtles on a cube above the band. Fireworks rained down on the stage during The Inner Reaches of Outer. For I Am in Miami, Trey switched to an acoustic guitar and the band stood together at stage front with the four-mic a cappella setup. After the set, the band departed as holograms back up the colored tubes. Soul Planet contained Knuckle Bone Broth Avenue and Don't Doubt Me quotes. Mike quoted Thanksgiving in Death Don't Hurt Very Long. The start of Harry Hood included alternate lyrics (Holy Blankenstein).

The songs in this show were based on animals. Big Black Furry Creature From Mars and Harpua contained Little Squirrel quotes. Shaggy Dog was played for the first time since June 22, 2012 (332 shows). I Am The Walrus was played for the first time since July 29, 2017 (131 shows). and featured Little Squirrel and Shipwreck quotes. Runaway Jim was unfinished and included a Hey, Ho, Nobody Home tease from Trey. Harpua was performed for the first time since July 30, 2017 (130 shows) and featured Carini, Your Pet Cat, and If 6 Was 9 quotes as well as This Jesus Must Die scatting from Trey. Part of Harpua was spoken in French by Page and Mike.

Trey and Mike quoted Little Squirrel throughout the first set (after Olivia’s Pool, and during Axilla and Weekapaug Groove), and during the final vocal chorus of Reba. Trey teased Martian Monster in Mike’s Song and Who Knows in I Always Wanted It This Way. Reba contained a verse with an Ass Handed quote by Trey in the final vocal chorus. Trey teased Tweezer during Sand.

This show featured a setlist with all songs featuring a number in their name in descending order including the Phish debut of If 6 Was 9 and several bustouts: 1999 (last played July 26, 2017, or 131 shows), Five Years (last played October 31, 2016, or 148 shows), Two Versions of Me (last played November 27, 2009, or 436 shows), and NO2 (last played September 6, 2015, or 193 shows). Trey teased L.A. Woman in Also Sprach Zarathustra and Seven Below in First Tube. Page teased Frankenstein in 1999. In place of the usual number of days lived, Grind featured the band singing the setlist ended by noting that the songs added up to “4,680 digits.”

Weekapaug Groove included a Call to the Post tease. Fish quoted Death Don’t Hurt Very Long in Carini. Scents and Subtle Sounds didn’t include the intro. Trey teased Crosseyed in Also Sprach Zarathustra. Page teased Hold Your Head Up at the end of Character Zero.

if I Could was played for the first time since July 29, 2014 (159 shows). DWD included In the Summertime and Oye Como Va teases from Trey and was unfinished. Trey quoted Everything is Hollow in Sneakin' Sally. The first HYHU contained a The Final Hurrah quote. Bike was played for the first time since September 4, 2015 (113 shows).

Trey teased Jean Pierre in Wolfman’s Brother, Third Stone From the Sun in Chalk Dust Torture, and Cool Amber and Mercury in NMINML. Fuego and Twist contained Pictures of Matchstick Men teases. Fish quoted The Final Hurrah in I Been Around. Hood contained We Are Come to Outlive Our Brains teases from Mike and Trey and quotes from Fish.

Ghost contained a Buried Alive tease from Trey. Trey teased Crazy Sometimes in Halley's Comet. The second set was billed as Kasvot Växt’s i Rokk and consisted entirely of debuts. Kasvot Växt would ultimately turn out to be a fictional band created by Phish with a detailed backstory and fake information added onto various websites. The band came out for the set dressed in white with an altered stage setup and twelve squares hanging from the ceiling illuminated. Antelope contained a quote of The Final Hurrah.

Carini and Antelope featured lyrics altered to reference Trey's shirt. Trey teased Martian Monster in Free and Undermind in Possum. The second set "musical costume" was David Bowie's The Rise and Fall of Ziggy Stardust and the Spiders From Mars. All of the songs in the second set were Phish debuts. Five Years, Soul Love, Moonage Daydream, Starman, and Rock 'n' Roll Suicide featured a string sextet comprised of Sylvia D'Avanzo (violin), Alisa Horn (cello), Todd Low (viola), Antoine Silverman (violin), Alissa Smith (viola), and Hiroko Taguchi (violin). All the songs in the second set other than Five Years, Lady Stardust, and Ziggy Stardust featured Jennifer Hartswick, Celisse Henderson and Jo Lampert on backing vocals. Trey played acoustic guitar on Five Years, Soul Love, Starman, and Lady Stardust. Trey did not play guitar (but contributed lead vocals) on It Ain't Easy and Rock 'n' Roll Suicide. Page did not play keyboards (but contributed lead vocals) on Ziggy Stardust. Carmel Dean arranged the all of the vocals and strings in the second set. Twist featured Trey on Marimba Lumina and Mike and Page on percussion. Also Sprach Zarathustra contained Fame quotes from Trey.

DWD was unfinished. The Birds was quoted after Birds of a Feather. Fuego contained Birds of a Feather and The Birds teases. Have Mercy was played for the first time since June 4, 2011 (221 shows).

Trey teased Call To The Post at the end of Gumbo. Scents did not have the intro. Mike teased Live and Let Die in Tweezer. I Always Wanted It This Way featured Trey on Marimba Lumina.

Trey teased San-Ho-Zay during No Men In No Man's Land and Sand in Golden Age. Simple contained a Nothing's Gonna Stop Us Now tease from Trey and Page. Dogs Stole Things was played for the first time since June 17, 2012 (182 shows). Beauty of My Dreams was played for the first time since December 31, 2010 (227 shows). Crimes of the Mind was played for the first time since November 29, 2009 (283 shows).

Mexican Cousin was played for the first time since June 19, 2012 (110 shows). Page teased Rhapsody In Blue at the end of Halfway to the Moon. Free, Walls of the Cave, Bowie, and the YEM vocal jam contained Martian Monster quotes. Chalk Dust was unfinished and ended with Fish teasing The Wedge. Toward the end of the YEM jam, Trey picked up his megaphone and began using the siren on it as he ran around the stage. Mike joined him, and Trey held the megaphone up to Mike's bass. Mike then began playing his fight bell with drum sticks while Trey went to the drums and played along with Fish.  Finally, Mike and Page joined in, so that all four were playing on Fish's kit. After Page thanked the audience and crew, Mike teased The Load-Out.

Dog Faced Boy was played for the first time since June 8, 2011 (144 shows). Birds of a Feather contained teases and quotes from The Birds. Twist contained Lengthwise quotes, Manteca teases and quotes, a Smoke on the Water tease and Your Pet Cat teases.

The backdrop on the stage at the start of the show was a large gate adorned with a "P." During Lawn Boy, Page introduced Mike as "Michael Gordleone" and Fish took a drum solo. Trey teased Saw It Again during Tube and San-Ho-Zay during Wolfman's. The musical costume was a set of original, mostly instrumental music played with the sound effects and narration of the 1964 Disneyland album Chilling, Thrilling Sounds of the Haunted House. Prior to the start of Set II, the stage was cleared of all band equipment, and a graveyard set was brought out. At the start of the set, smoke filled the stage, and zombies appeared behind the gate. When the gate opened, a large haunted house with the band inside was brought to the front of the stage. The sound effects and narration were played on the PA, while an undead narrator would emerge from a crypt inscribed with "ESTHER" prior to each song for the introduction. At the end of The Fuse, the sides of the house came down while sounds of an explosion were heard, and the band was revealed inside, dressed in white tuxedoes and with zombie face paint. Several zombies came to the front of the stage and danced during Martian Monster. At the conclusion of the set, the band members came down from the Haunted House riser, slowly walked to the front of the stage, and took bows, along with the entire cast of zombies. All songs during the second set were debuts, with the titles taken from the first ten tracks of Chilling, Thrilling Sounds of the Haunted House. Sand contained a tease by Trey of School's Out. Is This What You Wanted was a Phish debut. Page performed Frankenstein on keytar, which was played for the first time since July 1, 2012 (100 shows).