Page performed Frankenstein on keytar. Ghost included a San-Ho-Zay tease from Trey. Spooky was performed for the first time since April 14, 1993 (754 shows). The second set "musical costume" was Little Feat's Waiting for Columbus. Join the Band (the first track of Waiting for Columbus) was played over the P.A. before the start of the second set. Subsequently, Phish was introduced by Kevin Statesir (founder of Higher Ground) as "Little Feat" before Fat Man in the Bathtub. In the tradition of some of Phish's previous crowd experiments in the early '90s, flyers explaining a new Secret Language prank were included in the Phishbills that were passed out to fans as they walked into the show. The prank, designed to confuse those who would later listen to the recording, consisted of an announcer introducing Phish (as Little Feat). When the announcer would say a letter of the band FEAT ("Give me an F!"), the crowd would respond with letters corresponding to PHISH ("P-H!"). All of the songs in the second set other than Time Loves a Hero were Phish debuts. All of the songs in the second set, other than Don't Bogart That Joint and Willin', featured Giovanni Hidalgo on percussion. A five piece horn section consisting of Aaron Johnson on trombone, Stuart Bogie on saxophone, Ian Hendrickson-Smith on saxophone, Michael Leonhart on trumpet, and Eric Biondo on trumpet joined the band for Old Folks Boogie, Time Loves a Hero, Day or Night, Mercenary Territory, Spanish Moon, Dixie Chicken, Rocket in My Pocket and Feats Don't Fail Me Now. Willin' featured Page on bass, Mike on piano, Trey on drums and Fish on vocals. Prior to the piano solo at the beginning of Willin', Fish remarked, "That's supposed to be Bill Payne on the keyboard." Don't Bogart That Joint was performed a cappella. Trey introduced the guest musicians at the start of Feats Don't Fail Me Now and Page teased "Charge!" during the introductions. At the conclusion of the second set, the entire band marched the perimeter of the floor. Disease was unfinished, was initially botched, and had to be restarted, prompting Fish to declare, "This one's off our album." Julius featured Giovanni Hidalgo and the Waiting for Columbus horn section.

Whole Lotta Love was incomplete (one verse only) and was played for the first time since March 1, 1991 (1,037 shows). Wolfman's contained a vocal jam. Ha Ha Ha, Gin, Possum, Tweezer, and Tweezer Reprise all contained Whole Lotta Love teases and the Bowie intro contained a Whole Lotta Love quote from Trey. Squirming Coil contained The Rain Song and Thank You teases from Page and Possum also contained a Sneakin' Sally tease. The incomplete versions of Heartbreaker, Thank You, and Stairway to Heaven were all Phish debuts. Ramble On was played for the first time since August 12, 1998 (307 shows). After Stairway to Heaven, Trey joked, "Happy Halloween! See you all next year." Mike teased The Lemon Song before Halley's. Appropriately, Whole Lotta Love was also the post-show music. From the soundcheck, Ramble On and the second and third versions of Whole Lotta Love were incomplete. Destiny Unbound was played by only Mike and Fish, started out as being sung to the drumbeat of Time Loves A Hero and included a Live and Let Die quote from Mike.

Moma Dance was unfinished.

After Midnight was played for the first time since December 31, 1999 (208 shows). In Alumni, Trey added "from Goddard College" after the final "'cause I got a degree" lyric. Makisupa included the lyrics "Woke up this morning with a policeman at my door all I could do was shrug, and go back in my bedroom and smoke another nug." This show featured the Phish debut of Night Nurse; original artist Gregory Isaacs passed away the night before, October 25, 2010. Weekapaug was heavily teased by Trey in Mango before the segue into Weekapaug itself. Weekapaug subsequently contained a Can't You Hear Me Knocking jam, which featured lyrics from Ghost and Night Nurse, and was unfinished.

Ride Captain Ride was played for the first time since December 10, 1999 (216 shows). Stash contained a brief Dave's Energy Guide tease from Trey. Trey sang verses of Fee through a megaphone.

During Party Time, Trey wished "Kevin" a happy birthday (Kevin is the owner of Higher Ground in Burlington). Tweezer Reprise featured band members singing the refrain to Meatstick in place of the Tweezer Reprise lyrics. Prior to Down With Disease, Mike teased the Leave It To Beaver theme. The end of Disease contained a Curtain tease from Mike. Disease was unfinished and My Friend did not contain the "Myfe" ending. Piper contained a Maze tease and YEM included Wilson teases.

Wolfman's included a vocal jam, as well as a Streets of Cairo tease from Trey. The "dry ice factory" line in Cities was changed to "Genesee factory." Bowie featured Guyute teases throughout the intro, as well as several sections of Wilson jamming with Guyute lyrics during the song proper. Wilson, Saw it Again and Antelope all included Guyute teases from Trey, and Page also teased Guyute at the very end of Antelope (This show is referred to by many fans as "Guyutica"). The Antelope intro also contained Wilson and Nellie Kane teases from Mike. Wilson also had its lyric changed to "I must inquire Guyute" and Trey teased Guyute instead of saying "Marco Esquandolas" in Antelope. Piper contained Birds of a Feather teases. This show was officially released as Live In Utica.

Mike's Song contained a Fuck Your Face tease. Fast Enough for You started with Fish playing the drumbeat to I Am Hydrogen. Reba contained a Manteca quote from Fish and did not have the whistling ending.  

The YEM vocal jam contained Guy Forget quotes.

Bill Bailey featured Page’s dad, Dr. Jack McConnell, on vocals and tap shoes. Antelope's Marco Esquandolas lyric was changed to "Mike-O." Disease was unfinished.

Carini's lyrics were changed to reference a suspected outbreak of Bubonic plague in the Broomfield area. The first of the trapped miners in Chile emerged during the setbreak, and the second during Theme -> Free > Joy. After Meatstick's conclusion, the audience continued the song and dance for several choruses.

Reba did not have the whistling ending. What Things Seem made its Phish debut. Antelope included a call-and-response between Trey ("Marco!") and the audience ("Polo!").

Ghost featured a Bowie tease from Fish. Trey sang the verses of Fee through a megaphone. Before Fee, Trey waved the megaphone around. He also waved it around during Fee's coda and used it to create feedback during the first Makisupa. Makisupa included the lyrics "Woke up this morning alien on my face, woke up in the afternoon and I turned up the bass" and a subsequent bass solo from Mike. This show featured the debut of My Problem Right There.

This show marked Phish’s first appearance at the Austin City Limits Music Festival. Hood was unfinished.